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Deciphering the pharmacological mechanism of Guan-Jie-Kang in treating rat adjuvant-induced arthritis

Hudan Pan, Yanfang Zheng, Zhongqiu Liu, Zhongwen Yuan, Rutong Ren, Hua Zhou, Ying Xie, Liang Liu

《医学前沿（英文）》 2019年 第13卷 第5期   页码 564-574 doi: 10.1007/s11684-018-0676-2

摘要： Traditional Chinese medicine (TCM) formulas have attracted increasing attention worldwide in the past few years for treating complex disease including rheumatoid arthritis. However, their mechanisms are complex and remain unclear. Guan-Jie-Kang (GJK), a prescription modified from “Wu Tou Decoction,” was found to significantly relieve arthritis symptoms in rats with adjuvant-induced arthritis after 30-day treatment, especially in the 24 g/kg/day group. By analyzing 1749 targets related to 358 compounds in the five herbs of GJK, we identified the possible anti-arthritis pathways of GJK, including the calcium signaling and metabolic pathways. Bone damage levels were assessed by micro-computed tomography, and greater bone protective effect was observed with GJK treatment than with methotrexate. Receptor activator of nuclear factor κB ligand (RANKL)–RANK signaling, which is related to calcium signaling, was significantly regulated by GJK. Moreover, a target metabolomics assay of serum was conducted; 17 metabolic biomarkers showed significant correlations with treatment. An integrated pathway analysis revealed that pyruvate metabolism, purine metabolism, and glycolysis metabolism were significantly associated with the effects of GJK in arthritis treatment. Thus, this study establishes a new omics analytical method integrated with bioinformatics analysis for elucidating the multi-pathway mechanisms of TCM.

关键词： rheumatoid arthritis     traditional Chinese medicine     pharmacological mechanism     metabolism     adjuvant-induced arthritis     omics analysis    

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A case of primary neuroendocrine breast carcinoma that responded to neo-adjuvant chemotherapy

null

《医学前沿（英文）》 2015年 第9卷 第1期   页码 112-116 doi: 10.1007/s11684-014-0345-z

摘要：

Primary neuroendocrine breast carcinoma (NEBC) is a very rare type of breast cancer. Two characteristic biomarkers, namely, CgA and Syn, should be immunohistochemically detected to diagnose NEBC. In this study, a 43-year-old woman with a large mass of 8.3 cm × 2.9 cm in her right breast was reported. The patient was pathologically diagnosed with NEBC after specific markers, including CgA and Syn, as well as few differential markers, such as CK7, ER, PR, C-erbB-2, NSE, and E-cadherin, were immunohistochemically detected. The patient showed a remarkable response to four cycles of neo-adjuvant chemotherapy (partial response based on RECIST criteria) and sequentially underwent modified radical mastectomy. Moreover, the diagnosis and treatment of NEBC based on this case and available related literature were discussed.d literature were discussed.

关键词： neuroendocrine carcinoma     neo-adjuvant therapy     breast    

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Adjuvant chemotherapy versus adjuvant concurrent chemoradiotherapy after radical surgery for early-stage

《医学前沿（英文）》 2023年 第17卷 第1期   页码 93-104 doi: 10.1007/s11684-021-0892-z

摘要： We conducted a prospective study to assess the non-inferiority of adjuvant chemotherapy alone versus adjuvant concurrent chemoradiotherapy (CCRT) as an alternative strategy for patients with early-stage (FIGO 2009 stage IB–IIA) cervical cancer having risk factors after surgery. The condition was assessed in terms of prognosis, adverse effects, and quality of life. This randomized trial involved nine centers across China. Eligible patients were randomized to receive adjuvant chemotherapy or CCRT after surgery. The primary end-point was progression-free survival (PFS). From December 2012 to December 2014, 337 patients were subjected to randomization. Final analysis included 329 patients, including 165 in the adjuvant chemotherapy group and 164 in the adjuvant CCRT group. The median follow-up was 72.1 months. The three-year PFS rates were both 91.9%, and the five-year OS was 90.6% versus 90.0% in adjuvant chemotherapy and CCRT groups, respectively. No significant differences were observed in the PFS or OS between groups. The adjusted HR for PFS was 0.854 (95% confidence interval 0.415–1.757; P = 0.667) favoring adjuvant chemotherapy, excluding the predefined non-inferiority boundary of 1.9. The chemotherapy group showed a tendency toward good quality of life. In comparison with post-operative adjuvant CCRT, adjuvant chemotherapy treatment showed non-inferior efficacy in patients with early-stage cervical cancer having pathological risk factors. Adjuvant chemotherapy alone is a favorable alternative post-operative treatment.

关键词： chemotherapy     cervical cancer     lymph node metastasis     concurrent chemoradiotherapy     quality of life    

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Adjuvant treatment strategy after curative resection for hepatocellular carcinoma

Wei Zhang, Bixiang Zhang, Xiao-ping Chen

《医学前沿（英文）》 2021年 第15卷 第2期   页码 155-169 doi: 10.1007/s11684-021-0848-3

摘要： Hepatic resection represents the first-line treatment for patients with resectable hepatocellular carcinoma (HCC). However, the 5-year recurrence rates of HCC after surgery have been reported to range from 50% to 70%. In this review, we evaluated the available evidence for the efficiency of adjuvant treatments to prevent HCC recurrence after curative liver resection. Antiviral therapy has potential advantages in terms of reducing the recurrence rate and improving the overall survival (OS) and/or disease-free survival of patients with hepatitis-related HCC. Postoperative adjuvant transarterial chemoembolization can significantly reduce the intrahepatic recurrence rate and improve OS, especially for patients with a high risk of recurrence. The efficacy of molecular targeted drugs as an adjuvant therapy deserves further study. Adjuvant adoptive immunotherapy can significantly improve the clinical prognosis in the early stage. Randomized controlled trial (RCT) studies evaluating adjuvant immune checkpoint inhibitors are ongoing, and the results are highly expected. Adjuvant hepatic artery infusion chemotherapy might be beneficial in patients with vascular invasion. Huaier granule, a traditional Chinese medicine, has been proved to be effective in prolonging the recurrence-free survival and reducing extrahepatic recurrence. The efficiency of other adjuvant treatments needs to be further confirmed by large RCT studies.

关键词： hepatocellular carcinoma     adjuvant treatment     hepatic resection     recurrence    

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Optimising the oil phases of aluminium hydrogel-stabilised emulsions for stable, safe and efficient vaccine adjuvant

《化学科学与工程前沿（英文）》 2022年 第16卷 第6期   页码 973-984 doi: 10.1007/s11705-021-2123-1

摘要： To increase antibody secretion and dose sparing, squalene-in-water aluminium hydrogel (alum)-stabilised emulsions (ASEs) have been developed, which offer increased surface areas and cellular interactions for higher antigen loading and enhanced immune responses. Nevertheless, the squalene (oil) in previous attempts suffered from limited oxidation resistance, thus, safety and stability were compromised. From a clinical translational perspective, it is imperative to screen the optimal oils for enhanced emulsion adjuvants. Here, because of the varying oleic to linoleic acid ratio, soybean oil, peanut oil, and olive oil were utilised as oil phases in the preparation of aluminium hydrogel-stabilised squalene-in-water emulsions, which were then screened for their stability and immunogenicity. Additionally, the underlying mechanisms of oil phases and emulsion stability were unravelled, which showed that a higher oleic to linoleic acid ratio increased anti-oxidative capabilities but reduced the long-term storage stability owing to the relatively low zeta potential of the prepared droplets. As a result, compared with squalene-in-water ASEs, soybean-in-water ASEs exhibited comparable immune responses and enhanced stability. By optimising the oil phase of the emulsion adjuvants, this work may offer an alternative strategy for safe, stable, and effective emulsion adjuvants.

关键词： pickering emulsion     vaccine adjuvant     alum-stabilised emulsion     oleic to linoleic acid ratio     stability    

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Influence of the adjuvant therapy on the survival of patients with stage II pancreatic carcinoma

Xi-Yan WANG, Hai-Jun LI, Dong YAN, Hao WEN, Shu-Yong PENG,

《医学前沿（英文）》 2010年 第4卷 第4期   页码 430-435 doi: 10.1007/s11684-010-0700-7

摘要： This study aimed to investigate the effect of adjuvant therapy on the treatment of stage II pancreatic carcinomas. The clinical data of 139 cases of stage II pancreatic carcinoma were analyzed retrospectively. The overall 1-, 3-, and 5-year cumulative survival rates of 139 patients were 40%, 6%, and 3%, respectively, and the median survival time (MST) was 279 days. The MST was 399 days for those with adjuvant therapy, 210 days for those without adjuvant therapy, 390 days for the radical resection group, 270 days for the bypass operation and laparotomy group, and 132 days for the nonsurgical group. The adjuvant therapy could not prolong the survival time and decrease the liver metastasis rate of the patients with stage II carcinoma significantly in radical resection group (>0.05). In the bypass operation and laparotomy group and nonsurgical group, the adjuvant therapy could improve the survival of the patients significantly (<0.05); however, the survival rate was not significantly different among systemic venous chemotherapy, radiation therapy, interventional therapy, and combination therapy (>0.05); or between gemcitabine (GEM) regimen and 5-fluorouracil regimen (>0.05); or between GEM monotherapy and GEM combined with platinum/capecitabine (>0.05). The proper adjuvant therapy can be suggested according to the general condition of the patients after radical resection for stage II pancreatic carcinoma. Chemotherapy combined with radiation should be applied actively for the patients whose cancerous tissues were not radically resected. The clinical efficacy of GEM combined with platinum/capecitabine is relatively better than GEM.

关键词： pancreatic neoplasms     neoadjuvant therapy     survival    

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益生菌辅助治疗类风湿关节炎的益处：随机对照临床试验荟萃分析和系统综述 Article

潘胡丹, 李润泽, 李婷, 王俊, 刘良

《工程（英文）》 2017年 第3卷 第1期   页码 115-121 doi: 10.1016/J.ENG.2017.01.006

摘要：

肠道和口腔菌群是影响类风湿关节炎(rheumatoid arthritis, 简称类风关) 发生、发展的重要因素。

关键词： 类风湿关节炎     临床试验     益生菌辅助     系统综述     荟萃分析    

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blood monocular cells by triptolid is associated with TNF-alpha-308 gene polymorphisms in rheumatoid arthritis

Xiu-Liang TAO MM, Sheng-Hao TU MD, Ri-Bo XIONG MM, Yong-Hong HU BM,

《医学前沿（英文）》 2010年 第4卷 第2期   页码 220-224 doi: 10.1007/s11684-010-0025-6

摘要： This study examined the inhibitory effect of triptolid (TP) on tumor necrosis factor-α (TNF-α) secreted from peripheral blood monocular cells (PBMCs) and the association of the inhibitory effect with TNF-α-308 gene polymorphisms in rheumatoid arthritis (RA) patients. Gene polymorphism at A-G site 308 in the promoter region of TNF-α gene was detected in 42 RA patients by using allele specific polymerase chain reaction (AS-PCR) assay. PBMCs were harvested from these patients and treated first with lipopolysaccharides (LPS) and then with different doses of TP (1, 5.4 and 15 ng/mL). The TNF-α level in the supernatants was measured by enzyme-linked immunosorbent assay (ELISA). The results showed that TNF-α level in the supernatants of TP (1 ng/mL)-treated PBMCs was decreased by 3.80% and 4.91%, respectively, in the patients with AA and AG genotypes, when compared with those treated with LPS alone (>0.05). Moreover, the TNF-α level in the patients with GG genotype was reduced by 20.74% (<0.05). When PBMCs were treated with TP at 5.4 ng/mL, TNF-α levels in the patients with AA, AG, and GG genotypes were decreased by 20.42%, 34.73%, and 41.69%, respectively (<0.05). The TNF-α level was slightly higher in the PBMCs treated with 15 ng/mL of TP than those in the two TP groups in the patients carrying AA, AG, and GG genotypes (>0.05). It was concluded that gene polymorphism at TNF-α-308 sites may relate to the secretion of TNF-α in RA patients. TP has different inhibitory effects on the secretion of TNF-α in the patients harboring different genotypes, which may be one of the reasons for individual variation in response to TP.

关键词： arthritis     rheumatoid     molonuclear cells     tumor necrosis factor     gene polymorphisms     triptolid    

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Treatment of gingival hyperplasia induced by cyclosporine A

MA Jingzhi, LI Ming, CAO Yingguang

《医学前沿（英文）》 2008年 第2卷 第3期   页码 290-294 doi: 10.1007/s11684-008-0055-5

摘要： The clinical therapy for cyclosporine A (CsA)-induced gingival hyperplasia (GH) and the pathological changes in hyperplastic gingival tissues were investigated. Nine cases of CsA-induced GH after renal transplantation were subjected to periodontal non-surgical treatment and surgical treatment and were followed up. Gingival index (GI), dental plaque index (PLI) and GH degree (GHD) at different time points were measured. Under light and electron microscopy, the pathological changes in hyperplastic gingival tissues were observed. The CsA concentrations in gingival tissues and blood were determined by using fluorescence polarization immunoassay with TDFL monoclonal antibody. The results showed that GI, PLI and GHD in patients with GH declined after periodontal treatment. Two patients suffered from different degrees of GH during the 6 months to 54 months post-transplantation. Under transmission electron microscopy, fibroblasts in the hyperplastic gingival tissues were enlarged, cytoplasmic rough endoplasmic reticula were abundant and expanded slightly, and a few fibroblasts with early apoptotic changes were seen. The concentrations of CsA in hyperplastic gingival tissues were from 351.00 to 1345.47 ng/mL, which were significantly higher than in the blood of the same patients taken at the same time points. It was concluded that GI and PLI declined after periodontal treatment in combination with surgical treatment in patients taking CsA for a long time, but in some patients, GH recurred. The fact that the concentration of CsA in hyperplastic gingival tissues is higher than in blood awaits further studies.

关键词： post-transplantation     Gingival     cytoplasmic     CsA-induced     further    

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传统中医药治疗类风湿性关节炎——从经验医学到循证医学 Review

潘胡丹, 肖瑶, 王婉莹, 任汝通, 梁丽娴 , 刘良

《工程（英文）》 2019年 第5卷 第5期   页码 895-906 doi: 10.1016/j.eng.2019.01.018

摘要：

类风湿关节炎（RA）是一种常见的自身免疫性疾病，病因难以捉摸。常规和生物疾病缓解药物有时会失效或仅产生部分反应。中药（TCM）长期以来一直在中国用作RA的治疗方法，并在世界范围内得到越来越多的接受。传统上，中医治疗以中医辨证论治为指导。但是，它们仍然依赖于中医理论和医生进行经验实践

关键词： 中药，类风湿关节炎，循证治疗，展望    

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Influence of fluid-structure interaction on vortex induced vibration and lock-in phenomena in long span

Nazim Abdul NARIMAN

《结构与土木工程前沿（英文）》 2016年 第10卷 第4期   页码 363-384 doi: 10.1007/s11709-016-0353-y

摘要： In this paper, deck models of a cable stayed bridge are generated in ABAQUS-finite element program once using only CFD model (one-way fluid-structure interaction) and another by using both the CFD model and the CSD model together (two-way fluid-structure interaction) in a co-simulation. Shedding frequencies for the associated wind velocities in the lock-in region are calculated in both approaches. The results are validated with Simiu and Scanlan results. The lift and drag coefficients are determined for the two approaches and the latter results are validated with the flat plate theory results by Munson and coauthors. A decrease in the critical wind velocity and the shedding frequencies considering two-way approach was determined compared to those obtained in the one-way approach. The results of the lift and drag forces in the two-way approach showed appreciable decrease in their values. It was concluded that the two-way approach predicts earlier vortex induced vibration for lower critical wind velocities and lock-in phenomena will appear at lower natural frequencies of the long span bridges. This helps the designers to efficiently plan and consider for the design and safety of the long span bridge against this type of vibration.

关键词： vortex-induced vibration     fluid-structure interaction     Strouhal number     lock-in     kinetic energy    

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Formation of microporous polymeric membranes via thermally induced phase separation: A review

Min Liu,Shenghui Liu,Zhenliang Xu,Yongming Wei,Hu Yang

《化学科学与工程前沿（英文）》 2016年 第10卷 第1期   页码 57-75 doi: 10.1007/s11705-016-1561-7

摘要： A review of recent research related to microporous polymeric membranes formed via thermally induced phase separation (TIPS) and the morphologies of these membranes is presented. A summary of polymers and suitable diluents that can be used to prepare these microporous membranes via TIPS are summarized. The effects of different kinds of polymer materials, diluent types, cooling conditions, extractants and additive agents on the morphology and performance of TIPS membranes are also discussed. Finally new developments in TIPS technology are summarized.

关键词： polymer     microporous membrane     thermally induced phase separation    

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An overview of vortex-induced vibration (VIV) of bridge decks

Teng WU, Ahsan KAREEM

《结构与土木工程前沿（英文）》 2012年 第6卷 第4期   页码 335-347 doi: 10.1007/s11709-012-0179-1

摘要： A brief overview of vortex-induced vibration (VIV) of circular cylinders is first given as most of VIV studies have been focused on this particular bluff cross-section. A critical literature review of VIV of bridge decks that highlights physical mechanisms central to VIV from a renewed perspective is provided. The discussion focuses on VIV of bridge decks from wind-tunnel experiments, full-scale observations, semi-empirical models and computational fluids dynamics (CFD) perspectives. Finally, a recently developed reduced order model (ROM) based on truncated Volterra series is introduced to model VIV of long-span bridges. This model captures successfully salient features of VIV at “lock-in” and unlike most phenomenological models offers physical significance of the model kernels.

关键词： vortex-induced vibration (VIV)     Volterra series     bridge    

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Synthesis and ultraviolet/aggregation-induced emission investigation of novel tetraphenylvinyl hydrazone

《化学科学与工程前沿（英文）》 2023年 第17卷 第12期   页码 2061-2073 doi: 10.1007/s11705-023-2366-0

摘要： Herein, three novel tetraphenylethylene hydrazone chemosensors TC12, SC16, and TC16 are prepared for the selective detection of F−. Two NH and one C=N units are incorporated into the sensors for better colorimetric responses, whereas the tetraphenyl unit is in charge of the aggregation-induced emission effect. Among them, compounds SC16 and TC16 form stable gels with some organic solvents. All the tetrahydrofuran/H2O solutions of the three compounds exhibit aggregation-induced emission effect, whereby the fluorescence emission increases by varying degrees with the volume of poor solvent water. Moreover, good aggregation-induced emission effects are observed in the self-assembly of SC16 and TC16. As a sample chemosensor, TC12 in tetrahydrofuran responds to F− selectively with high sensitivity, with the colorimetric and fluorometric detection limits of 8.25 × 10−7 mol·L–1 and 2.69 × 10−7 mol·L–1, respectively. The reversible gel-sol-gel phase transition and color changes indicate that both SC16-dimethyl sulfoxide and TC16-ethyl acetate gels specifically respond to F– with good sensitivity. The detection results are well supported by ultraviolet-visible spectroscopy, fluorescent spectroscopy, and 1H nuclear magnetic resonance. More importantly, the driving forces of gelation are visually clarified through the single crystal X-ray analysis of compound TOMe.

关键词： organogelator     tetraphenylvinyldrazone     single crystal     aggregation-induced emission effect     ion sensing    

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Cellular changes in bronchoalveolar lavage fluid in hyperoxia-induced lung injury

HE Xinbiao, ZHAO Wei

《医学前沿（英文）》 2008年 第2卷 第4期   页码 370-373 doi: 10.1007/s11684-008-0071-5

摘要： It is well known that high concentration oxygen exposure is a model of acute lung injury (ALI). However, controversy exists over the mechanism. This study was designed to clarify the cellular characteristics in bronchoalveolar lavage fluid (BALF) and body weight loss of rats exposed to oxygen(> 90%). Young male Wistar rats, aged 6 weeks, were divided into three groups: (1) room air group (exposed to room air, = 22); (2) hyperoxia < 48 h group (exposed to over 90% oxygen for less than 48 h, = 18); (3) hyperoxia 66–72 h group (exposed to over 90% oxygen for 66–72 h group, = 7). Compared to the room air group, the total cell counts in the hyperoxia 66–72 h group decreased, whereas the neutrophils increased significantly. The body weights of the rats exposed to room air continued to increase. However, the body weights of oxygen-exposed rats increased slightly on the first day and weight loss was seen from the second day. All rats were noted to have bilateral pleural effusion in the hyperoxia 66–72 h group. The data suggests that (1) an increase in neutrophil count is an evident feature of hyperoxia-induced lung injury; (2) high concentration oxygen exposure can give rise to anorexia and malnutrition, which may play a role in hyperoxia-induced lung injury. Blocking neutrophil influx into lung tissue in the early phase and improving malnutrition are two effective methods to reduce hyperoxic lung injury.
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标题 作者 时间 类型 操作

Deciphering the pharmacological mechanism of Guan-Jie-Kang in treating rat adjuvant-induced arthritis

Hudan Pan, Yanfang Zheng, Zhongqiu Liu, Zhongwen Yuan, Rutong Ren, Hua Zhou, Ying Xie, Liang Liu

期刊论文

A case of primary neuroendocrine breast carcinoma that responded to neo-adjuvant chemotherapy

null

期刊论文

Adjuvant chemotherapy versus adjuvant concurrent chemoradiotherapy after radical surgery for early-stage

期刊论文

Adjuvant treatment strategy after curative resection for hepatocellular carcinoma

Wei Zhang, Bixiang Zhang, Xiao-ping Chen

期刊论文

Optimising the oil phases of aluminium hydrogel-stabilised emulsions for stable, safe and efficient vaccine adjuvant

期刊论文

Influence of the adjuvant therapy on the survival of patients with stage II pancreatic carcinoma

Xi-Yan WANG, Hai-Jun LI, Dong YAN, Hao WEN, Shu-Yong PENG,

期刊论文

益生菌辅助治疗类风湿关节炎的益处：随机对照临床试验荟萃分析和系统综述

潘胡丹, 李润泽, 李婷, 王俊, 刘良

期刊论文

blood monocular cells by triptolid is associated with TNF-alpha-308 gene polymorphisms in rheumatoid arthritis

Xiu-Liang TAO MM, Sheng-Hao TU MD, Ri-Bo XIONG MM, Yong-Hong HU BM,

期刊论文

Treatment of gingival hyperplasia induced by cyclosporine A

MA Jingzhi, LI Ming, CAO Yingguang

期刊论文

传统中医药治疗类风湿性关节炎——从经验医学到循证医学

潘胡丹, 肖瑶, 王婉莹, 任汝通, 梁丽娴 , 刘良

期刊论文

Influence of fluid-structure interaction on vortex induced vibration and lock-in phenomena in long span

Nazim Abdul NARIMAN

期刊论文

Formation of microporous polymeric membranes via thermally induced phase separation: A review

Min Liu,Shenghui Liu,Zhenliang Xu,Yongming Wei,Hu Yang

期刊论文

An overview of vortex-induced vibration (VIV) of bridge decks

Teng WU, Ahsan KAREEM

期刊论文

Synthesis and ultraviolet/aggregation-induced emission investigation of novel tetraphenylvinyl hydrazone

期刊论文

Cellular changes in bronchoalveolar lavage fluid in hyperoxia-induced lung injury

HE Xinbiao, ZHAO Wei

期刊论文